Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
AUTOR: Alejandro Corvalán
Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
Rev Méd Chile 2007; 135: 257-263
In the early stages of breast cancer, surgery and radiotherapy arrest the local and regional disease. However 30% of patients will die as a consequence of tumor dissemination. Parameters with a relative predictive value are used to assess candidates to adjuvant therapy. Genomic analysis methods (cDNA microarray) identified a gene expression profile of greater aggressiveness in breast cancer. This knowledge generated the project “Translating Molecular Knowledge Into Early Breast Cancer Management” of the Breast International Group (BIG). This is a consortium of 32 research groups in which Chile participates through the Chilean Cooperative Oncological Research Group (GOCCHI). The project consists in three protocols. In the first, denomimated MINDACT (Microarray for Node Negative Disease may Avoid Chemotherapy), 8000 women will be evaluated by gene expression profile and clinical pathological criteria to decide adjuvant therapy. Since a group of patients will not receive therapy, solely based on gene expression profile, GOCCHI is preparing a follow up protocol based on the expression of 22 genes. MINDACT is the first prospective effort to evaluate gene expression profiles in clinical practice. Our participation in this protocol, installs us in the first line of worlwide oncological investigation (Rev Méd Chile 2007; 135: 257-63).
Recibido el 28 de marzo, 2006. Aceptado el 7 de septiembre, 2006.
Financiamiento: Proyectos TRANSBIG-MINDACT, European Union Sixth Framework
Programme Proposal, PG 39/04 Pontificia Universidad Católica de Chile y Proy 05/05 Dirección
Académica Clínica Las Condes.
Laboratorio Biología Molecular - Departamento Anatomía Patológica, Pontificia Universidad
Católica de Chile y 2Grupo Oncológico Cooperativo Chileno de Investigación (GOCCHI).
Correspondencia a: Dr. Alejandro Corvalán. Lira 85 4º piso.